Simparica Trio 5.6-11 lbs

DESCRIPTION:

Simparica Trio Chewable Tablets for Dogs are used to prevent Dirofilaria immitis-related heartworm disease in dogs. It also treats and controls roundworms, adult hookworms, and ticks, kills adult fleas, and prevents and treats flea infestations.

Key Benefits: Simparica Trio contains:

• Sarolaner, an insecticide and acaricide that blocks glutamate-gated and GABA chloride channels in the acarine and insect nervous system. This causes increased stimulation of the nerves, then parasite death.
• Selamectin works to paralyze and/or kill a broad range of parasites (invertebrates) by interfering with the conductance of their chloride channels.
• This disrupts normal transmission, inhibiting nerve cell electrical activity of nematodes and muscle cells of arthropods. This causes paralysis and/or death of the parasite.
• Pyrantel Pamoate, a tetrahydropyrimidine nematocide that depolarized and blocks the neuromuscular transmission of susceptible parasites, leading to paralysis and death or elimination.
• Moxidectin, a macrocyclic lactone endectocide that interferes with the parasite’s chloride channel-mediated neurotransmission, causing paralysis and parasite death.

  Formulated For: For dogs and puppies 8 weeks or older and weigh 2.8 lbs or more.

  How is Medication Given? Dosage Recommendations:

• Dogs 2.8 to 5.5 Pounds: One Tablet Containing 12.5 mg Pyrantel, 0.06 mg Moxidectin, and 3 mg Sarolaner
• Dogs 5.5 to 11 Pounds: One Tablet Containing 25 mg Pyrantel, 0.12 mg Moxidectin, and 6 mg Sarolaner
• Dogs 11 to 22 Pounds: One Tablet Containing 50 mg Pyrantel, 0.24 mg Moxidectin, and 12 mg Sarolaner
• Dogs 22 to 44 Pounds: One Tablet Containing 100 mg Pyrantel, 0.48 mg Moxidectin, and 24 mg Sarolaner
• Dogs 44 to 88 Pounds: One Tablet Containing 200 mg Pyrantel, 0.96 mg Moxidectin, and 48 mg Sarolaner
• Dogs 88 to 132 Pounds: One Tablet Containing 300 mg Pyrantel, 1.44 mg Moxidectin, and 72 mg Sarolaner
• Feed without or with food.
• Ensure that your dog has consumed his or her full dose and that no part is refused or lost.
• If you miss a monthly dose, administer right away and resume the monthly schedule.
• Administer orally once monthly.
• If your dog is currently infested with ticks, he or she should be evaluated before treatment to identify the tick species.
• Recommended dosage rate is 0.54 mg of Sarolaner per pound of body weight, 2.27 mg per pound of pyrantel (pamoate), and 0.011 mg per pound of moxidectin.

  What Results Can I Expect? Simparica Trio: Controls and treats adult hookworm and roundworm infections. Prevents and treats flea infestations. Controls and treats ticks (American dog, brown dog, Gulf Coast, black-legged, and lone star). Prevents heartworm disease.

  What Form Does Medication Come In? Chewable Tablet

  Dose and Administration: Sold as a 6-month (6-dose), weight-based supply.

  Possible Side Effects: Potential adverse reactions include:

• Polydipsia
• Hyperactivity
• Polyuria
• Anorexia
• Lethargy
• Diarrhea
• Vomiting Simparica Trio contains Sarolaner, an isoxazoline drug. This drug class is associated with certain neurological effects, including:
• Seizures
• Ataxia
• Tremors
  These effects are possible whether or not the dog has a history of a neurological condition. Administer cautiously to a dog with a known neurological disorder.

  Precautions: Not effective against D. immitis in the adult stage. Before use, dogs should receive a heartworm test to rule out an existing infection. Dogs with heartworm infections will require treatment, as determined by a veterinarian, to remove the adult worms. Not proven safe for use in lactating, pregnant, or breeding dogs. Keep out of reach of animals and children. Never administer to a human.

  Storage Recommendations: Store in a cool and dry location between 59 degrees – 86 degrees F (15-30 degrees C).

  In Case of Overdose: Call your nearest emergency pet hospital.

Studies to support FDA approval showed that1 dose of Simparica Trio provided 100% protectionagainst heartworm disease

Heartworm disease is a year-round threat that has been diagnosed in all 50states. Clinics reported a 21% increase in heartworm positive cases in a 3 yearperiod.⁸

Infection iswidespreadacross the US

as shown by salesof 1 heartwormtreatment⁹

Map based on 2018Diroban^® (melarsominedihydrochloride) sales.